• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    COMPONENT PACKAGING STRUCTURE FOR PHARMACEUTICAL CONTAINERS. The invention relates to a component packaging structure (17) for pharmaceutical containers comprising at least one tray (10) having at least one open side for introducing and extracting at least one support shelf (11) which is parallel to a background (14) of the tray (10) and which rests in correspondence with the inner walls (15) of the tray (10); wherein said support shelf (11) has a spatially predetermined distribution of said first supports or cavities (13) within which the closure components and/or generic accessories of said containers, such as rubber caps (17), nuts (20) with bezel fitting or other types of caps and/or sealing nuts are placed, so that the vertical geometric axis of each closure component is perpendicular to said bottom plane (14) of the tray (10), being that said structure then constitutes a guarantee of sterility and cleanliness of said closing components and/or generic accessories that are inserted in said supports or cavities (13).
    公开号:BR112015003534B1
    申请号:R112015003534-5
    申请日:2013-08-28
    公开日:2021-05-11
    发明作者:Fabiano Nicoletti；Giuseppe Fedegari
    申请人:Stevanato Group International A.S.；Fedegari Autoclavi S.P.A；
    IPC主号:
    专利说明:

    [001] The present invention relates, in general, to a packaging structure of components for pharmaceutical containers.
    [002] In particular, the invention relates to a component packaging structure, in which the components have technical resources so that they are maintained in an isolated and controlled environment, as well as a chemically or physically stable, clean, sterile environment , non-toxic, until its use or application in the implantation process (filling and closing) of ampoules, vials, syringes and other pharmaceutical containers.
    [003] Known component packaging structures for pharmaceutical containers comprise a tray made of plastic material and have a closed bottom carrying an inner plane or matrix (so-called "nest") made of plastic material and having a series of housing holes in which the containers are placed in an upright position, as described in WO2009/015862A1.
    [004] Some containers, such as syringes, are held in position thanks to the fact that a perimeter flange of the container rests against the edge of the housing holes, while other containers that do not have protruding parts require specific elements to be housed inside holes.
    [005] The plastic tray is sealed by means of a porous membrane filter, such as a paper filter or a Tyvek® filter, and is also protected by an additional closed container consisting of a flexible film that has an opening hidden by a Tyvek® or porous filtration membrane.
    [006] Therefore, the packaging structure comprises at least two superimposed sterility barriers that are capable of interrupting any particulate or microbiological contamination; it is also possible to add other containers in order to have more sterility barriers.
    [007] Said insulated packages are then placed inside containers made of plastic or corrugated cardboard, which have the proper size and weight to be manually exchanged during the packing and unpacking operations.
    [008] Containers are generally stacked and placed on pallets before being subjected to a final sterilization cycle (with gas).
    [009] Finally, when the products have to be used, they are sent to a controlled contamination area, for example, a sterile zone through an aseptic filling process; the operation consists of unpacking the units, opening the outer container with reduced contamination (the operation is normally performed with an ultra-clean laminar air flow, thus protecting the surface), extracting the package after a biological decontamination of the external surface and placing said package in the aseptic zone, before removing the Tyvek® filter from the tray.
    [0010] However, the known component packaging structure for pharmaceutical containers, as described, has limited flexibility of use as it cannot be used universally and efficiently to package other components that are provided for the assembly of the containers. pharmaceuticals, such as rubber stoppers to close the vials, sealing rings made, for example, of snap-locking devices and/or aluminum which are placed in correspondence with the container opening.
    [0011] In addition, even the components mentioned above must necessarily be kept in an isolated and controlled sterile environment until their use and, therefore, they are still packaged inside the respective sterile packages ready for use.
    [0012] The different components are then oriented in the right direction, for example, by means of an active bolus and then sorted into a number of tracks in which an automated device picks them up and guides them to a final position of mounting.
    [0013] It is clear that the system described above does not allow the automated management of sets of different components through the handling of containers, which assembles and eventually closes the automated devices since, for example, if the two components are assembled in a single container (such as a rubber cap and sealing ring) the system must be duplicated, with consequent additional operating costs and relative difficulties in changing container sizes by means of automated component assembly, handling and retrieval devices.
    [0014] Furthermore, each package that is capable of specifically containing the relative component must be prepared, cleaned and sterilized each time container sizes are changed.
    [0015] An aim of the present invention is therefore to overcome the above mentioned disadvantages of the prior art and particularly to provide a component packaging structure for filling pharmaceutical containers which is multi-purpose and which allows at the same time after filling of containers through automatic machines and without the assistance of any operator, an automated management of the different sets of other accessories that can be used sporadically.
    [0016] Another objective of the present invention is to provide a packaging structure of components for pharmaceutical containers that ensures the sterilization of the locking and closing components and accessories that are normally needed to complete the filling process of the containers, which guarantees maintenance of its qualitative characteristics, its integrity, its identification and possibility of traceability, as well as the transfer and safe assembly of said accessories.
    [0017] A further objective of the invention is to provide a packaging structure of components for pharmaceutical containers that makes easy the assembly and handling operations of containers and components, thus reducing the total cost of the final product.
    [0018] Advantageously, the packaging structure, according to the invention, allows to have the different components or accessories (such as tampons, clips, pressure lock, etc.) to be placed in the pharmaceutical container, so that the they are immediately ready for use, as they are oriented in a correct direction and positioned in a certain place and they can then be removed and assembled by means of automated mounting and collapsing devices (robots) that can be pre- programmed depending on the size of the different containers; the robot can also be programmed to perform the correct sequences of assembly and handling steps to complete the pharmaceutical container.
    [0019] This allows the use of dedicated production lines for small quantities and for different sizes, thus achieving significant savings in operating costs, simplicity and efficiency of assembly and handling operations, as well as speed and efficiency in changing the sizes of the containers.
    [0020] The additional features and advantages of the packaging structure of components for pharmaceutical containers, which is the purpose of the present invention, will become clearer from the following description in relation to a preferred embodiment and from the drawings cited, in that: - Figure 1 is a top plan view of an element used in a first embodiment of the component packaging structure for pharmaceutical containers, according to the present invention; Figure 2 is a side view of the element of Figure 1, according to the present invention; figure 3 is a sectional view along line III-III of figure 4 of said first embodiment of the packaging structure of components for pharmaceutical containers, according to the present invention; Figure 4 is a top plan view of said first embodiment of the component packaging structure for pharmaceutical containers of Figure 3, in accordance with the present invention; figure 5 is a sectional view taken along line V-V of figure 1, according to the invention; - Figure 6 shows an enlargement of the details indicated with C in Figure 3; Figure 7 is a perspective view in cross-section of the packaging structure of components for pharmaceutical containers of the previous figures, according to the present invention; - Figure 8 shows an enlargement of the details indicated with D in figure 7; Figure 9 shows an enlargement of a detail of a possible alternative embodiment of the component packaging structure for pharmaceutical containers, according to the present invention.
    [0021] With reference to the drawings mentioned above, the packaging structure of components for pharmaceutical containers, which is the object of the present invention, comprises a tray 10, which is normally made of plastic material and which has an open upper side for inserting and extracting a first shelf or flat element 11 that holds the pharmaceutical containers; said first flat element 11 is also made of plastic material, such as polypropylene, and is positioned parallel to the bottom plane 14 of tray 10.
    [0022] Said open upper side of tray 10 is sealed with a porous filtering membrane and tray 10 may also have a cover or protective wrapping for its transfer in a controlled area (for example, an area where the filling of containers occurs ); the protective cover can be opened or closed and can include a quick transfer port.
    [0023] Furthermore, each protective covering may contain one or more stacked trays 10 and/or one or more flat support elements 11 and is formed at least partially of a sheet made of a material that is selectively permeable to a traditional sterilization process .
    [0024] The flat support element 11 has a flat top surface and a substantially rectangular shape and has pairs of opposite parallel edges that rest on a side shoulder formed on the inner walls 15 of the tray 10 (as shown in detail in Figures 7 and 8 cited); said edges are stable in position through boundary means, such as, for example, projections made on the tray 10 which are counterparts of the respective cavities which have a conjugated shape and made on the flat element 11 (or, conversely, projections made on the flat element 11 which are counterparts of the respective cavities provided in the tray 10).
    [0025] In addition, said flat support element 11 has a predetermined spatial distribution of vertical supports 13, within which the closures of containers, such as sealing rings 20 made, for example, of locking devices by snapping and/ or aluminum are placed at a predetermined distance from each other; said closing and/or locking devices have their longitudinal geometric axis perpendicular to the background 14 of the tray 10.
    [0026] According to a first embodiment of the present invention, a shelf or flat support element 12 is superimposed on the flat support element 11; the flat element 12 also has a flat surface and is also shaped to have a series of cavities or supports 16 which have an upper surface 18 of a suitable geometry and placed in correspondence with the respective vertical supports 13 of the flat member 11.
    [0027] In particular, the components that are provided to completely assemble the pharmaceutical containers, such as the rubber stoppers 17, are inserted and retained in position within the cavity 16 of the flat support element 12, as plastic or aluminum seals, such as the ferrules 20 and/or the snap-locking devices of the containers (bottles, cartridges) are also placed inside the supports 13 of the lower flat element 11.
    [0028] Specifically, the cavities 16 of the flat support element 12 are made so that the rubber plugs 17 are housed and held in a certain position and in a correct orientation; rubber plugs 17 can be placed, one for each cavity 16 in the upper surface 18 which corresponds to the entrance area of the pharmaceutical components.
    [0029] The upper flat surface of the flat support element 12 also allows to place the protective membrane above the cavities 16 thus allowing the insertion of each single flat support element 11, 12 or a series of flat support elements 11, 12 stacked inside an additional protective cover.
    [0030] Alternatively, components such as rubber plugs 17 and crimp ferrules 20 can also be pre-assembled together before being placed on bearings 16; for example, the rubber plugs 17 and the locking devices of said plugs 17 may first be assembled together and then positioned, as one piece, within the respective cavities 16 of the flat support element 12, while the devices have a diameter that is substantially equal to or less than the diameter of the glass container, it is possible to use the flat support element 11 to also house the locking devices (such as the rubber plugs 17 and the ferrules or nuts 20), which are pre-assembled inside the cavities 13 of the flat support element 11.
    [0031] Furthermore, the flat support elements 11, 12 have both the same general external dimensions and the same arrangement of the cavities or supports 13, 16, so as to be easily stacked, and said cavities or supports 13, 16 also they are advantageously shaped according to a matrix, in order to protect the closure components, such as the caps 17 and/or the ferrules 20, from impacts, contacts, deformation, surface pressures, etc.
    [0032] According to other embodiments, more than two flat support elements 11, 12 can be stacked.
    [0033] The respective shaped areas 19 are also provided between the cavities 16 of the flat support element 12; the areas 19 have a suitable shape to ensure a certain integrity and strength of the structure and a perfect vertically centering between the flat support elements 11 and 12, and between the supports 13 and 16 of the respective flat elements 11 and 12.
    [0034] According to a further embodiment of the present invention, it is also possible to avoid the flat support element 12 and then provide for the insertion of the flat support element 11, of locking devices, such as rubber plugs or latches 17, and the crimping ferrules 20 which are already pre-assembled and directly coupled inside the supports 13 of the flat support element 11; advantageously, this solution allows to avoid the use of a component (the flat support element 12), thus, the production of savings and operating costs, since the relative sterilization problems that are related to the handling of said flat support element 12 are also avoided.
    [0035] The packaging structure formed in this way is used to directly and automatically feed pharmaceutical containers and related closure components, such as covers 17 and ferrules 20 that are contained therein and that are placed in spatially prefixed positions, to a process machine for its manipulation.
    [0036] Typically, the process machine comprises an automated device or arm (robot) that includes a gripping member suitable for handling each of the closure components.
    [0037] The flat support elements 11, 12, filled with the respective closing or locking components, which are grouped in oriented rows, after being extracted from the tray 10 (without the upper closing element), are moved towards a robot head retract position, which must, after filling the pharmaceutical containers, assemble the different locking or closing components, such as rubber plugs 17, crimping ferrules 20 or other seals and/or locking devices by snap with ability to close the pharmaceutical container.
    [0038] Therefore, it is clear that, according to the present invention, it is possible to treat simultaneously along only one aseptic filling line, with independent support plane elements 11, 12 that contain the closing or locking components, such as rubber stoppers or latches 17, snap-locking devices, seals and/or crimping ferrules 20, related to the size of the pharmaceutical containers, which you thereby obtain directly, in a short time and extremely effective, the finished product.
    [0039] The aseptic filling line requires, in fact, that the containers and the closing and locking components are initially prepared (washed and sterilized) and are subsequently introduced into said aseptic area without any contamination of the environment or components.
    [0040] Therefore, along the transfer line of said closure components and containers (electron beam, plasma, etc.), chemical and/or physical processes (vaporized hydrogen peroxide, peracetic acid, chlorine dioxide, etc.) .) that have the ability to obtain a surface decontamination are carried out.
    [0041] In another embodiment of the invention, the trays 10, closed with the filter membrane are packed inside a container that has a sterile transfer port, which can be placed in correspondence with the wall of the aseptic zone, in which the fixed portion corresponding sterile transfer port is provided; then, trays 10 are directly transferred into the aseptic zone without any contamination.
    [0042] In any case, according to the present invention, said transfer line can be planned so as to transfer both the flat support elements that house the pharmaceutical containers and the flat support elements 11, 12 that contain the components closures in order to achieve complete sterility and cleanliness of all elements through a single process and quickly and effectively carry out a change in size of the glass containers and related closure components.
    [0043] If more than two flat support elements 11, 12 housing the closure components are provided, they can be stacked together in a single external container, in order to further reduce operating costs and improve treatment effectiveness .
    [0044] The technical features of the packaging structure of components for pharmaceutical containers, which is the object of the present invention, are clear from the above description, as well as the related advantages are also clear.
    [0045] Finally, it is clear that other variants can be made to the packaging structure of the invention without departing from the principles of novelty inherent to the inventive idea as claimed in the cited claims, as it is clear that in the practical implementation of the invention the materials , formats and sizes of the technical details can be any depending on the requirements, and can be replaced by another technically equivalent.
    权利要求:
    Claims (8)
    [0001]
    1. Component packaging structure (17) for pharmaceutical containers comprising at least one tray (10) having at least one open side for introducing and extracting at least a first support shelf (11) that is parallel to a plane of bottom (14) of the tray (10), wherein said at least one first support shelf (11) rests in correspondence with the inner walls (15) of said tray (10) and has a spatially predetermined distribution of the first supports or cavities (13) into which the closure components and/or generic accessories of said containers, such as rubber caps (17), nuts (20) with crimp fitting or other types of caps and/or sealing nuts are placed so that the vertical geometric axis of each closure component is perpendicular to said bottom plane (14) of the tray (10), wherein said structure then constitutes a guarantee of sterility and cleanliness of said closure components and/or generic accessories that are inserted in said supports or cavities (13), said at least one first support shelf (11) of said closure components being coupled to at least one second support shelf (12) that is parallel to said at least one first support shelf (11) of said closure components and which has a spatially prefixed distribution of second supports or cavities (16) provided in correspondence with said first supports or cavities (13) of said at least one first support shelf (11) of said closure components, characterized in that rubber plugs or caps (17) are inserted and held in position within said second supports or cavities (16) of said at least one second support shelf (12) while plastic and/or aluminum seals, such as ferrules (20) and/or snap-locking devices of the containers are placed within said first s rests or cavities (13) of said at least one first support shelf (11), which is flat and is placed lower than said at least one second support shelf (12).
    [0002]
    2. Packaging structure, according to claim 1, characterized in that said rubber caps or covers (17) are placed one for each of said second supports or cavities (16) and on an upper surface (18 ) of said second supports or cavities (16) corresponding to an entry area of pharmaceutical components.
    [0003]
    3. Packaging structure, according to any one of the preceding claims, characterized in that at least two of said closure components are pre-assembled together before being inserted into said first (13) or second (16) supports or cavities.
    [0004]
    4. Packaging structure, according to any one of the preceding claims, characterized in that said open side of the tray (10) is sealed by means of at least one porous filtering membrane.
    [0005]
    5. Packaging structure, according to any one of the preceding claims, characterized in that said tray (10) is enclosed within at least one protective envelope that is formed, at least partially, from a sheet made of a selectively permeable material.
    [0006]
    6. Packaging structure, according to any one of the preceding claims, characterized in that said protective casing contains one or more stacked trays (10) and/or one or more of said support shelves (11, 12) of said containers and/or said closure components.
    [0007]
    7. Packaging structure, according to claim 1, characterized in that said closure components are pre-assembled within said first (13) or second (16) respective supports or cavities.
    [0008]
    8. Packaging structure, according to any one of the preceding claims, characterized in that between said second supports or cavities (16) of said second support shelf (12), respective shaped areas (19) are formed in order to ensure integrity and solidity to the structure, and a perfect centering in the vertical direction between said first and second support shelves (11, 12) and between said first (13) and second (16) supports or cavities of the respective support shelf (11,12).
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    同族专利:
    公开号 | 公开日
    US20150238263A1|2015-08-27|
    WO2014033766A1|2014-03-06|
    IN2015DN01399A|2015-07-03|
    CN104755115A|2015-07-01|
    MX2015002143A|2015-07-06|
    ITVI20120215A1|2014-03-01|
    JP2015528344A|2015-09-28|
    CA2882689A1|2014-03-06|
    JP6347783B2|2018-06-27|
    EP2890423B1|2016-08-24|
    CA2882689C|2020-04-28|
    EP2890423A1|2015-07-08|
    MX353118B|2017-12-20|
    CN104755115B|2017-12-12|
    US9718583B2|2017-08-01|
    BR112015003534A2|2017-07-04|
    ES2599552T3|2017-02-02|
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    法律状态:
    2018-11-21| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-11-19| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-04-13| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-05-11| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/08/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    ITVI20120215|ITVI20120215A1|2012-08-30|2012-08-30|STRUCTURE FOR PACKAGING COMPONENTS FOR PHARMACEUTICAL CONTAINERS|
    ITVI2012A000215|2012-08-30|
    PCT/IT2013/000230|WO2014033766A1|2012-08-30|2013-08-28|Components packaging structure for pharmaceutical containers|
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